Diablo 5 gameplay details from BlizzCon: More classes than ever before, procedurally-generated dungeons, and Diablo 2-style loot

Diablo 5 is set to introduce several significant changes from its predecessor, Diablo 4. The sequel will be taking place a century after the events of Diablo 4, in the aftermath of Diablo's destruction of Sanctuary. The developers revealed that the game will feature a more dynamic combat system, a larger roster of classes, and a revamped loot system.

Much of the story takes place in the aftermath of Diablo's reign, as Sanctuary struggles to recover. The campaign begins as Sanctuary falls into the hands of Diablo, with the player tasked with restoring the western continent and Westmarch, the most iconic location in the series. The demon hunter and monk classes will return, while a new class, the plague knight, will join the roster. The plague knight is a heavily-armored class that spreads disease around the battlefield.

Procedurally-generated dungeons and open-world regions will be a prominent feature of the game, ensuring that every return to these areas offers a unique experience. Towns will no longer exist, replaced by a caravan of NPCs that the player will encounter throughout the story. The caravan will include a treasure goblin as a companion. Sidequests will all come from the people in the caravan.

Items in Diablo 5 will have multiple tiers, starting simple and growing in complexity as the player progresses. Belts and set items are making a return, and items will take up multiple inventory slots based on their type, similar to Diablo 2. The developers emphasized that they will be gathering regular updates on the development of Diablo 5 starting next year, and that the game will be evolving based on player feedback.