Bills Wire game-by-game predictions for the 2026 NFL season

The Buffalo Bills are gearing up for their 2026 NFL season, which is just around the corner. Week 1 against the Houston Texans has arrived, and the Bills aim to avenge recent Houston losses. Joe Brady makes his head coaching debut in Week 1. The Bills start their season with a 1-0 record.

In Week 2, the Bills host the Detroit Lions at Highmark Stadium. A victory in this matchup is crucial for the Bills, and they are expected to secure a 2-0 record.

The Bills face the Los Angeles Chargers at home in Week 3. A high-scoring game is anticipated, and the Bills are expected to win, bringing their record to 3-0.

Week 4 sees the Bills travel to face the New England Patriots. After a losing effort in the AFC East last season, the Bills are motivated to bounce back in 2026, aiming for a 4-0 record.

A Week 5 matchup against the Los Angeles Rams at LA's LA Memorial Coliseum is predicted to be a challenging game for the Bills. The Rams could be the best team in the NFL, leading to a 4-1 record for the Bills.

Week 6 features a road game against the Las Vegas Raiders. The Bills are expected to dominate a rebuilding Raiders team, bringing their record to 5-1.

Week 7 is a bye week for the Bills, maintaining a 5-1 record.

In Week 8, the Bills host the Baltimore Ravens at Highmark Stadium. The loss of Sean McDermott as head coach is expected to impact the game, resulting in a 5-2 record.

Week 9 at home against the Minnesota Vikings is predicted to be a Bills win, regardless of whether Kyler Murray or J.J. McCarthy starts as quarterback. The Bills are expected to secure a 6-2 record.

A Week 10 game against the New York Jets at MetLife Stadium is predicted to be a Bills victory, despite the Jets' recent roster overhaul. The Bills maintain a 7-2 record.

In Week 11, the Bills face the Miami Dolphins at Hard Rock Stadium. The Dolphins could be the top overall pick at the 2027 NFL Draft, but the Bills are expected to secure a 8-2 record.

Week 12 at home against the Kansas City Chiefs on Thanksgiving features a potential post-bye drop for the Bills. However, the Bills' motivation against the Chiefs is expected to carry them to a 9-2 record.

A Week 13 game at the New England Patriots at Gillette Stadium is predicted to result in a split-season record, with the Bills at 9-3.

The Bills are predicted to struggle against the Green Bay Packers in Week 14 at Lambeau Field. The desire to return to winning ways is expected to keep the Bills at a 10-3 record.

Week 15 against the Chicago Bears at Soldier Field is uncertain, but the Bills are expected to face a surprising loss, keeping their record at 10-4.

In Week 16 at Denver's Sports Authority Field at Mile High, the Bills' revenge desire for the Broncos is expected to lead to a win, with the record at 10-5.

Week 17 at the Miami Dolphins at Hard Rock Stadium is predicted to be a Bills win, regardless of the Dolphins' performance, bringing the Bills' record to 11-5.

The Bills' final game of the season, Week 18 against the New York Jets at Highmark Stadium, is predicted to be a win for the Bills if they have something to play for, resulting in a 12-5 record.