PD-L2 Blockade May Reduce Harmful Aging Cell Buildup
Blocking PD-L2 reduced senescent cell accumulation in aged mice and improved measures tied to metabolic function and physical strength. The post PD-L2 Blockade May Reduce Harmful Aging Cell Buildup appeared first on GEN - Genetic Engineering and Biotechnology News .
A study from Cedars-Sinai Health Sciences University suggests that targeting a protein called PD-L2 could help reduce the accumulation of aging cells, called senescent cells, in tissues. Senescent cells accumulate with age and contribute to age-related health problems. The study, titled "Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction," found that PD-L2 increases in senescent cells and with age in human tissues.
Blocking PD-L2 in mice led to fewer senescent cells, improved insulin sensitivity, and enhanced physical strength. Researchers from Cedars-Sinai and the Center for Advanced Gerotherapeutics caution that more research is needed to determine whether blocking PD-L2 can safely improve human health.
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