CypA is a molecular barrier to HIV emergence from Eastern chimpanzees
Of the two lineages of lentivirus that endemically infect chimpanzees, only one has served as a source of infections in hu-mans. Using HIV-CRISPR screening, we identify factors that limit the replication of lentivirus from Eastern chimpanzees. We find that CypA restricts nonzoonotic Eastern chimpanzee lentivirus due to a unique feature encoded in capsid. The ability of CypA to restrict lentivirus…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
