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Patient questionnaires may add a new layer to chronic lymphocytic leukemia prognosis

Patients' responses to questions routinely raised by oncologists may provide important clues about their chances of survival from chronic lymphocytic leukemia (CLL), according to a new study published in the journal Therapeutic Advances in Hematology.

Patient questionnaires may add a new layer to chronic lymphocytic leukemia prognosis

A new study published in Therapeutic Advances in Hematology suggests that patient questionnaires could provide valuable insights into the prognosis of chronic lymphocytic leukemia (CLL). Researchers analyzed data from 1,238 CLL patients who completed symptom questionnaires before starting ibrutinib-based treatment. By applying clinically meaningful thresholds to their responses, the study found that patient-reported outcomes (PROs) could help predict outcomes, improve prognosis, and identify individuals at higher risk.

Dr. Ahmad Y. Abuhelwa, the study's lead author, emphasizes that patients' own reports about their health could serve as a powerful new dimension to prognosis, treatment, and risk stratification. The study highlights that a large proportion of patients entering clinical trials have meaningful functional or symptom burdens that could be identified through direct questioning.

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