TST Best Bets: September 6, 2026

Ole Miss running back Kewan Lacy dominated a college football game against LSU, jumping over a defender and contributing to the team's 24-19 victory. The first full weekend of college football ended with two high-profile matchups featuring four teams making their season debuts. Louisville and Ole Miss faced off in Nashville, while Notre Dame and Wisconsin played at Lambeau Field. Today's TST Best Bets recommend betting the spread in both games to finish the week on a high note.

The first pick is Ole Miss -6.5 over Louisville. This line suggests Ole Miss needs to win by at least a touchdown in Nashville. The team has solid continuity under center, with Trinidad Chambliss returning from last season with 3,937 passing yards, 22 touchdowns, and only three interceptions. Joined by rookie running back Kewan Lacy, who totaled 1,567 yards and 24 rushing touchdowns, Ole Miss appears to have an advantage.

Louisville's passing game, led by transfer Lincoln Kienholz (250 career passing yards and one touchdown), is less proven. The Rebels are expected to pull away as the game progresses and cover the 6.5-point spread.

The second pick is Notre Dame -21 over Wisconsin. Wisconsin's defense showed promise, but its offense struggled, averaging just 12.8 points per game last season. Facing an injury-heavy Wisconsin team, Old Dominion transfer Colton Joseph brings needed playmaking ability, though he is still learning in a new offense. Noteworthy is Notre Dame's returning quarterback CJ Carr, who threw for 2,741 yards and 24 touchdowns in his first season.

Despite the loss of key players Jeremiyah Love and Jadarian Price, Notre Dame's offense is expected to be more reliable than Wisconsin's. The Irish's consistent high-scoring games (eight wins by more than 20 points) and ability to cover up against weaker defenses make them the better pick to cover the 21-point spread.