Brain signaling mechanism may explain clozapine weight gain
Researchers at UT Southwestern Medical Center have identified a key brain signaling pathway that appears to drive the substantial weight gain often associated with clozapine, a widely used antipsychotic medication. The preclinical findings, published in Nature Communications, point to a potential way to reduce the metabolic side effects of this medication, commonly prescribed for patients with…
Researchers at UT Southwestern Medical Center have discovered a brain signaling pathway that contributes to the weight gain associated with clozapine, an antipsychotic medication used to treat treatment-resistant schizophrenia. The findings, published in Nature Communications, suggest that blocking this pathway could potentially reduce the metabolic side effects of clozapine.
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