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5 Best College Football Picks Against the Spread for Week 1 Friday:

Week 1 rolls on with Michigan State, Purdue, and USC among the headliners as the Big Ten takes center stage. Here are the five best picks against the spread for Friday night.

1. Toledo at Michigan State: ATS Pick - Under

This game is considered a risky pick due to both teams having new coaching staffs, personnel changes, and a relatively low point total. Despite this, it is still a potential opportunity.

2. LIU at Kansas: ATS Pick - Kansas

The point spread favors Kansas heavily, but given the disparity between FBS and FCS teams, this pick may prove to be a solid choice. Kansas is expected to dominate this matchup.

3. Indiana State at Purdue: ATS Pick - Purdue

Purdue's offensive prowess and the recent struggles of Indiana State make this a strong candidate for an away win. The margin between the two teams is significant, further supporting the decision to pick Purdue.

4. Miami at Stanford: Over

Historical data suggests that when Miami wins by more than 24.5 points, they are likely to exceed the projected total of 47.5. Therefore, picking "Over" on the point total appears to be a viable choice for this game.

Written by urgent.news from Yahoo Sports's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.

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