Tumour rewires host tryptophan metabolism to promote organism-wide immune suppression
How tumour genotype reshapes systemic metabolism to drive immune tolerance and tumour progression remains unclear. Here, we show that Pten-deficient Drosophila tumours reprogram host tryptophan metabolism, triggering systemic and local changes in immune and stromal compartments to foster tolerance. Tumour-derived nitric oxide activates the kynurenine pathway in liver-like tissue, selectively…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
