Stroke and Alzheimer's disease have distinct consequences on neurovascular function but synergize to increase amyloid deposition
INTRODUCTION: We examined whether stroke induces chronic cerebrovascular dysfunction and thereby exacerbates A{beta} pathology. METHODS: We exposed Tg2576 mice to a transient mild subcortical ischemia and examined cerebrovascular function at chronic timepoints as well as reactive astrocytes and A{beta} deposition post-mortem. RESULTS: Baseline cerebral blood flow and cerebrovascular reactivity…
Stroke and Alzheimer's disease each bring unique impacts to neurovascular function. However, their combined effects seem to worsen amyloid deposition. Researchers examined the impact of a mild, temporary brain blockage in mice genetically engineered to develop Alzheimer's symptoms. They assessed changes to cerebral blood flow, neurovascular coupling, and accumulation of a protein implicated in Alzheimer's.
The study found that the protein strongly impairs blood flow regulation early on. Meanwhile, the brain blockage adversely affected regulation as the mice aged. Astonishingly, the mice that experienced both conditions exhibited reduced overall blood flow regulation, but an increase in the protein's presence. This suggests that stroke-induced vascular issues and Alzheimer's pathology interact in complex ways, but are not strongly linked.
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