Microdroplets may reduce colorectal tumor growth at potentially lower cost
Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed microscopic peptide droplets that deliver large amounts of gene-silencing molecules into cancer and immune cells, reducing the growth of hard-to-treat colorectal tumors by about 67% in mice. The patent-pending system uses small interfering RNA, or siRNA, to disrupt the production of two proteins that cancer…
Scientists from Nanyang Technological University in Singapore have developed microscopic peptide droplets that effectively reduce the growth of colorectal tumors by about 67% in mice. The innovative system uses small interfering RNA (siRNA) to disrupt the production of two proteins, PD-1 and PD-L1, which cancer cells exploit to evade immune attacks.
When combined, the siRNA treatments suppressed tumor growth to a level comparable with existing checkpoint immunotherapies, which use monoclonal antibodies costing five to 10 times more to produce. The NTU researchers estimate the siRNA-based approach could potentially be less expensive to develop and scale up.
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