Ectopic expression of the germline transcription factor LSL-1 contributes to developmental delay following failed maternal epigenetic reprogramming
Proper transmission of cell identity between generations requires maternal epigenetic reprogramming mechanisms that prevent inappropriate inheritance of lineage-specific transcriptional programs. In Caenorhabditis elegans, loss of the H3K4me1/2 demethylase SPR-5 and the H3K9 methyltransferase MET-2 results in ectopic expression of germline genes in somatic tissues and severe developmental delay.…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
