Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction
Nature Medicine, Published online: 01 September 2026; doi:10.1038/s41591-026-04573-6 Through exploration of serum proteomics from pregnancy cohorts, Miao et al. have shown that ISM2 is involved in extravillous trophoblast invasion and that lower levels in early pregnancy may indicate increased risk of preeclampsia and fetal growth restriction.
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