Arterial Elastin Abundance, Rather Than Orthologue Origin, Modulates Medial Arterial Calcification in Matrix Gla Protein-Deficient Mice
Abstract Calcific deposits in the arterial media have been associated with a number of metabolic and genetic disorders including diabetes, chronic kidney disease and generalized arterial calcification of infancy. While medial calcification and physiologic hard tissue mineralization in the skeleton are both regulated by several common determinants, emerging data suggest that there might be…
Medial arterial calcification, a condition linked to various metabolic and genetic disorders, can be influenced by the abundance of arterial elastin, not its origin, according to a study involving MGP-deficient mice. Researchers found that a humanized MGP-deficient model with 40% less medial elastin content exhibited no early-stage vascular calcification.
Both mouse and human elastin orthologues impacted vascular calcification in a similar manner. When arterial elastin abundance was reduced further, mineral deposition and maturation were significantly delayed. Conversely, reestablishing elastin levels via transgenic human ELN expression restored arterial calcification.
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