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Altered oligodendrocyte function promotes cognitive decline in aging

Nature Medicine, Published online: 01 September 2026; doi:10.1038/s41591-026-04630-0 Leveraging a human brain tissue bank with cognitive data across the lifespan, we identify a role for oligodendrocytes — myelin-producing cells in the brain — in age-related cognitive decline. With worsening cognitive decline, oligodendrocytes become dysfunctional and produce myelin of poor integrity, and…

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