Scientists uncover microbiome signaling system that could open new paths for IBS-related constipation
Mayo Clinic researchers have discovered that chemical signals produced by gut bacteria work together to control intestinal movement. One bacterial signal helps set the intestines in motion, while another primes gut cells to respond more strongly, amplifying the effect. The research expands scientists' understanding of how the gut microbiome communicates with the body, moving beyond the…
Researchers at Mayo Clinic have discovered a new signaling system involving chemical signals produced by gut bacteria that can control intestinal movement. The study, published in the Proceedings of the National Academy of Sciences, reveals that one bacterial signal prompts the release of serotonin, a chemical messenger that aids in moving food through the digestive tract, while another signal primes gut cells to respond more strongly to the first signal.
This discovery could lead to new microbiome-based treatments for constipation-predominant irritable bowel syndrome, a chronic condition marked by abdominal pain and constipation.
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