Popular sweeteners may leave effects that last for generations

Recent research in mice suggests non-nutritive sweeteners like sucralose and stevia may have long-lasting impacts on health that extend to future generations. These artificial sweeteners, commonly found in diet sodas and other foods, offer sweetness without calories but have raised concerns over possible adverse effects.

Scientists divided 47 mice into three groups, giving one plain water and the other two containing either sucralose or stevia. Both sweeteners altered the gut microbiome and gene activity, effects that persisted in later generations. Mice exposed to sucralose showed more persistent changes in inflammation and metabolism, even two generations later. While stevia also impacted genes, its effects were weaker and didn't last beyond one generation.

Impaired glucose tolerance emerged in first-generation males exposed to sucralose, and second-generation offspring of both sweetener groups showed elevated fasting blood sugar. The mice also had more diverse gut bacteria but lower levels of beneficial short-chain fatty acids, which may influence health through epigenetic mechanisms.

The study highlights the need for further research into the effects of non-nutritive sweeteners on metabolism and inflammatory processes. While the findings don't prove causation, they suggest that moderation in consumption and continued investigation are prudent steps, especially for those with existing metabolic concerns.