Colonization of the gut microbiota with Akkermansia muciniphila ameliorates dysbiosis-mediated transplant arterial injury in female mice
Background: Transplant arterial injury is an underlying feature of acute organ transplant rejection and is a main cause of late heart transplant failure. The role of the gut microbiota, and especially specific microbial components of this community, in controlling immune responses that cause this aspect of rejection is poorly understood. Methods: We utilized a murine aortic interposition model of…
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