Chemists develop method for the synthesis of natural compounds with potential in medicine
A team of scientists from the Department of Organic Chemistry at the Faculty of Science, Charles University, Prague, has reported a new method that simplifies the preparation of complex molecules. The work was published in the journal Organic Letters. Such molecules are related to natural compounds known for their anticancer and anti-inflammatory effects. The new approach could help scientists…
A team of organic chemists at the Charles University in Prague has devised a novel three-step synthesis technique for intricate natural compounds. These compounds, akin to galiellalactone derived from the fungus Galiella rufa, possess potent anticancer and anti-inflammatory properties. Their unique three-dimensional structures, composed of three linked rings, render them challenging to synthesize traditionally.
The new method significantly enhances control over the molecule's final structure, crucial for its potential biological effects. Preliminary tests on four types of cancer cells, including a chemotherapy-resistant form of prostate cancer, did not reveal direct toxicity. However, the approach allows for the systematic creation of additional variants for further biological evaluation.
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