Fractional exhaled nitric oxide elevated in pediatric chest tightness-variant asthma
Children with chest tightness variant asthma (CTVA) have higher fractional exhaled nitric oxide (FeNO) levels and lower measures of small airway function, according to a study published online Aug. 10 in Frontiers in Pediatrics.
Children diagnosed with chest tightness variant asthma (CTVA) in a Chinese retrospective case-control study exhibited elevated fractional exhaled nitric oxide (FeNO) levels and reduced forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow compared to healthy controls. Researchers from Cangzhou Central Hospital found that obesity, inhalant allergen sensitization, allergic rhinitis, atopic dermatitis, chronic respiratory infections, and family history of allergic diseases were significantly associated with CTVA.
However, further formal diagnostic accuracy studies are required to validate the use of combined FeNO and small airway indicators in diagnosing CTVA.
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