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Notch Signaling Switch Enables Scalable Helper T Cell Production for CAR T

By modulating Notch and T cell receptor signaling, scientists have produced functional CD4+ T cells from iPSCs, potentially advancing scalable, off-the-shelf CAR T therapies.

  • Researchers at Boston University develop scalable method for CD4+ helper T cell production.
  • Notch signaling pathway modulated to enable large-scale T cell maturation.
  • Study offers insights into T-cell biology and potential for off-the-shelf CAR T therapies.

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