Structural basis for nutrient-activated channel opening in bacterial spore germination receptors
GerA-family germinant receptors were recently identified as ion channels that initiate germination of dormant bacterial spores in response to nutrients. Here we report 2.0-[A] cryo-electron microscopy structures of apo, agonist-bound, and antagonist-bound GerA, revealing a symmetric pentamer of heterotrimers. Signaling relies on two allosteric switches that radiate from the LeuT-type…
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