SERBP1 is a master regulator of ribosome interactions
Ribosome function depends on interactions with diverse proteins whose activities determine translational efficiency, impose quality control and activate signaling pathways. These many competing activities must in turn be regulated. SERBP1 is an abundant cellular factor that interacts with ribosomes at multiple functionally critical sites on both dormant and active ribosomes. Here, we perform mass…
Ribosome function relies on intricate interactions between diverse proteins that regulate translational efficiency, quality control, and signaling pathways. These proteins must be tightly controlled to maintain proper cellular function. SERBP1 is a crucial cellular factor that interacts with ribosomes at critical sites on both dormant and active ribosomes.
Researchers conducted mass spectrometry experiments on sucrose gradients in untreated and stressed cells, discovering that SERBP1 modulates various factors involved in processes such as mRNA degradation, translational control, ribosome quality control, and ribosome degradation. By competing with the E3 ligase RNF10 and the atypical kinase RIOK3, SERBP1 plays a vital role in protecting ribosomes against selective 40S degradation in the context of mTOR inhibition.
The study establishes SERBP1 as a central player in maintaining ribosome subunit balance and regulating a wide range of ribosome activities.
Written by urgent.news from bioRxiv's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
