CysLENS: Interpretable signatures of cysteine ligandability from enantiomeric chemoproteomics and protein language models
Large chemoproteomic screens using covalent fragments map compound-cysteine engagements across the proteome, however, identifying robust, recognition-driven interactions remains a challenge due to experimental variability and electrophile reactivity. Here, we present CysLENS (Cysteine Ligandability Evaluation through Neighborhood and Chemical Similarity), an integrative framework that prioritizes…
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