Precision medicine identifies influential protein in bladder cancer progression and chemotherapy effectiveness
Researchers investigating the role of progranulin in cancer progression have previously identified the signaling receptor EphA2 as critical in tumor establishment and a potential target to enhance the effectiveness of chemotherapy. While the exact molecular mechanisms of action are still not well understood, the growth factor progranulin is known to be involved in several human pathologies,…
Researchers have identified a protein, FAM120A, that plays a significant role in bladder cancer progression and chemotherapy effectiveness. The protein is part of the progranulin/EphA2 signaling axis, which has been linked to tumor establishment and cancer growth. Through experiments on bladder cancer cell lines, researchers found that high levels of FAM120A correspond with increased progranulin-induced cancer proliferation.
Conversely, suppressing FAM120A reduced tumor growth and enhanced sensitivity to cisplatin, a common chemotherapy drug. This discovery could lead to new therapeutic strategies targeting FAM120A to reduce tumor malignancy and sensitize cancer cells to chemotherapy. FAM120A may also serve as a biomarker for diagnostic and prognostic purposes.
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