HIDE-Deconv: A hierarchical deconvolution framework for multiscale characterization of cellular remodeling

Most deconvolution methods estimate cellular composition at a single level of cellular resolution despite biological processes often manifesting within fine-grained cellular subpopulations. We present HIDE-Deconv, a hierarchical deconvolution framework that jointly optimizes cellular compositions across multiple levels of a cell-type hierarchy while maintaining consistency between resolutions. In…

biorxiv.org ·1d ago

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HIDE-Deconv: A hierarchical deconvolution framework for multiscale characterization of cellular remodeling

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