Alcama expressed in blood retina barrier and Muller glia is involved in zebrafish retina regeneration
Activated leukocyte cell adhesion molecule A (Alcama) plays a role in axonal guidance, cell differentiation, and retinal lamination in a developing retina and was identified as a marker for activated Muller glial cells in adult zebrafish. However, its spatiotemporal localization and its involvement in retina regeneration remains unclear. Here we induced focal photoreceptor damage in zebrafish…
Alcama, a protein involved in axonal guidance and retinal lamination, was found to be localized to the blood-retina barrier in both adult and developing zebrafish retinas. Researchers induced photoreceptor damage in zebrafish using laser photocoagulation and observed increased Alcama expression in Muller glial cells during retina regeneration.
By temporarily reducing Alcama expression through morpholino injections, the team discovered that retina regeneration was delayed in these altered fish. This suggests that Alcama may play a crucial role in the zebrafish retina regeneration process.
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