Trust-Aware Sequence-to-Function Modelling in Regulatory Genomics
Objective: Sequence-to-function models increasingly predict regulatory activity, such as chromatin accessibility, directly from DNA sequence, and are used to interpret non-coding genetic variation. Standard accuracy metrics, computed over a held-out set of genomic regions, do not establish whether an individual prediction remains reliable once the input sequence departs from that set, nor whether…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
