15 Years Younger: Professor Dean Ho Uses His Own Body to Study Aging
Professor Dean Ho, a biomedical engineer at the National University of Singapore (NUS), became the sole participant in a longevity study designed to track how his body responds to changes in fasting, exercise, nutrition and sleep. After about eight months of continuous monitoring, an artificial intelligence system estimated his biological age at about 32, nearly […]
Professor Dean Ho, a biomedical engineer at the National University of Singapore, has become the sole participant in a longevity study called DELTA, which aims to track how his body responds to changes in fasting, exercise, nutrition, and sleep. After eight months of continuous monitoring, an AI system estimated Ho's biological age at 32, nearly 15 years younger than his chronological age of 47.
The study, published in PLOS One on August 12, 2026, uses N-of-1 methodology, where Ho serves as his own test subject, and integrates time-restricted feeding, strength and cardiovascular training, a Mediterranean diet, and supplementation. Ho's physiological measurements, such as metabolic switching time, resting heart rate, sleep patterns, and gut microbiome, all showed significant improvements during the study.
The AI system analyzed these changes to estimate his biological age, a concept that differs from chronological age, which simply counts the years a person has been alive.
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