sc-pcQTL: hurdle-based co-expression modeling for multi-gene QTL mapping in single-cell RNA-seq data
Motivation: Single-cell expression quantitative trait locus (eQTL) studies can resolve cell-type-specific genetic effects, but conventional gene-by-gene analyses do not directly capture coordinated genetic regulation of neighboring genes. Principal-component QTL (pcQTL) mapping can summarize such multi-gene effects, but existing approaches were developed for bulk expression and are not designed…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
