Synchrotron Nano-FTIR Reveals Carbohydrate-Dependent Protein Conformational Changes at Bacterium-Nanoparticle Interfaces
Antimicrobial resistance motivates the development of approaches capable of probing nanoparticle-bacterium interactions with nanoscale sensitivity. Here, synchrotron infrared nano-spectroscopy (SINS) is applied to investigate interactions between carbohydrate-coated silica nanoparticles and the Gram-negative model bacterium Escherichia coli at the single-cell level. Silica nanoparticles (SiO2)…
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