Sleuth identifies dozens of studies that used the wrong antibody

A science sleuth has uncovered evidence suggesting that more than 50 studies examining cell ageing may have utilized the incorrect antibody to detect a crucial protein during their experiments, according to a recent report. The findings, published in a series of scientific papers, include:

1. Tront et al. (2010) in Cancer Research, 70:9671-9681, and Ocampo et al. (2016) in Cell, 167:1719-1733, were among the studies implicated in the sleuth's investigation.

2. The research reveals that a specific protein, Lsp2, plays a significant role in linking dietary restriction to increased lifespan in flies. The protein also connects early-life diet to adult translation and lifespan in Drosophila, as reported by Surprising protein links dietary restriction to increased lifespan in flies.

3. Further studies explore the relationship between hepatocytes, liver metastasis of pancreatic cancer, and the provision of serine. A design approach for bitopic kinase inhibitors and all the ways a cell can die — and why the variety matters are also discussed in the report.

4. The investigation uncovers a growing competition in the regenerative-medicine sector, while also highlighting the impact of China's actions against prominent academics exposed by a research sleuth.