Unsupervised detection of antimicrobial-resistance determinants by coupling protein-language-models and evolutionary signatures
Antimicrobial resistance (AMR) is among the most pressing threats to global health, yet our ability to find resistance determinants is largely confined to what reference databases already contain: homology search and supervised classifiers recognize variants of known genes but are, by construction, blind to the larger environmental and clinical reservoir of determinants that have not yet been…
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