Regulation of Mechanosensor PIEZO Channel Trafficking in C. elegans Germline

PIEZO proteins are essential mechanotransductive ion channels, yet mechanisms governing their subcellular localization and membrane trafficking remain elusive. Here, we leverage the C. elegans germline as an in vivo imaging platform to decipher the molecular networks directing PIEZO channel dynamics. High-resolution confocal imaging of endogenously tagged PEZO-1, the C. elegans ortholog, reveals…

biorxiv.org ·15h ago

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Regulation of Mechanosensor PIEZO Channel Trafficking in C. elegans Germline

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