Origins Anywhere and Everywhere: Genome replication requires cooperative activation of thousands of origins in each cell
Our model of replication dynamics in a single eukaryotic cell supplants current population-based models. Long-read sequencing reveals cooperative activation of ~8400 closely spaced origins in every S.cerevisiae cell. Origins with bidirectional forks of comparable velocities are evenly distributed across the genome. The probability of early origin activation directly correlates with the average…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
