Nanoparticle combines two strategies to speed up the healing of chronic wounds

Researchers at the University of São Paulo in Brazil have designed a nanoparticle that targets multiple factors inhibiting chronic wound healing. Chronic wounds, like diabetes-related ulcers and pressure ulcers, affect up to 2% of the population and pose significant health risks. The nanoparticle combines two strategies: silencing the MMP-9 enzyme responsible for tissue degradation and delivering resveratrol, a compound with antioxidant and anti-inflammatory properties.

The hybrid nanoparticle protects these molecules, enhances their penetration into the skin, and promotes gradual release at the wound site. Tests on cell cultures and porcine skin showed that the formulation significantly reduced MMP-9 production, lowered reactive oxygen species, and improved fibroblast migration, leading to nearly complete wound closure within 72 hours.

While promising, the technology is still in the research phase, with future steps including testing on three-dimensional skin models, animals, and eventually clinical trials. Researchers are also exploring the combination of these nanoparticles with platelet-rich plasma gel to further enhance tissue regeneration.