Loop statistics and fountain geometry reveal effective two-sided cohesin extrusion and crowding-induced arm desynchronization
Cohesin-driven loop extrusion shapes chromosome organization, yet what determines loop lengths and coordination between the extruding arms in vivo remains unclear. Broad extrusion "fountains" in Hi-C maps point to arm desynchronization, whose physical origin is unknown. Here we develop a kinetic theory of extrusion through transient chromatin roadblocks and neighbouring cohesins. Roadblock…
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