A natural glycolipid exposes the outer membrane interface as a tunable regulator of bacterial surface attachment.
Surface attachment initiates bacterial colonization and biofilm formation, yet remains difficult to target owing to redundant and species-specific mechanisms. Here we identify dalberoside, a natural glycolipid that inhibits adhesion by non-disruptive remodeling of the Gram-negative outer membrane interface. Dalberoside inhibited Pseudomonas aeruginosa and Acinetobacter baumannii attachment and…
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