The structural logic of insect olfactory receptor assembly and gating
Insects detect the chemical world using a large family of odorant-gated ion channels, each assembled from a variable odorant-binding subunit (OR) and a single conserved co-receptor Orco. This modular organization is thought to allow tuning ORs to diversify their chemical recognition while tOrco provides structural stability to the heteromer. Yet Orco can be autonomously activated by synthetic…
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