The px1 locus is linked to declining susceptibility to malaria drugs in Uganda
Nature Medicine, Published online: 19 August 2026; doi:10.1038/s41591-026-04624-y The emergence and spread of drug resistance threatens progress toward malaria control and elimination. We identified a rapidly spreading haplotype on chromosome 7 of Plasmodium falciparum that contains mutations and deletions in the px1 gene. This genomic locus is strongly associated with reduced susceptibility of…
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