Study finds sustained benefit for people using Oregon psilocybin services
People participating in an Oregon Health & Science University-led study of state-regulated psilocybin services reported relief from symptoms of anxiety, depression and post-traumatic stress disorder—with almost two-thirds declaring the experience to be among the most meaningful of their lives.
An Oregon-led study examining real-world outcomes of psilocybin services has found sustained benefits for individuals using state-regulated psilocybin programs. Published in JAMA Network Open, the research involved 346 participants who underwent a single psilocybin session at 24 licensed centers between November 2024 and June 2026.
Nearly two-thirds of participants said the experience was among the most meaningful of their lives. Lead author Dr. Todd Korthuis stated that safety results mirrored those in clinical settings, addressing concerns about translating safety from controlled trials to real-world use. Most participants reported improvements in depression, anxiety, and PTSD symptoms, with continued use by 90% of participants over three months.
Only seven participants reported the experience as harmful after three months, suggesting low adverse event incidence. While not suitable for those with psychosis, bipolar disorder, or pregnancy, the study indicates state-regulated psilocybin use is safe and may offer mental health benefits.
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