Structural and biochemical analysis of the Estrogen-Related Receptor alpha and complex with TMPRSS2 promoter DNA

In TMPRSS2 fusion-positive prostate cancer, ERR is involved in regulation of ERG and promotes the androgen receptor independent signaling in the cancer progression. The ERR binds to the ERREs (estrogen-related receptor response elements) present at -5042 bp of the TMPRSS2- promoter and enhances the ERG overexpression that causes prostate cancer progression. To dissect the structural basis of the…

biorxiv.org ·16h ago

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