OmegaSwitch: Bayesian Markov-Modulated Codon Models for Estimating dN/dS

Selective pressures can vary across both sites and evolutionary lineages; however, most codon models accommodate heterogeneity along only one of these dimensions and require the number of selective regimes to be specified in advance. Here, we introduce OmegaSwitch, a Bayesian phylogenetic software framework for inferring changes in the nonsynonymous-to-synonymous substitution-rate ratio (dN/dS)…

biorxiv.org ·22h ago

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