Nationwide real-world analysis of neuroendocrine tumors in Japan using the JMDC claims database

Herpes zoster, also known as shingles, is a common condition affecting Japanese women, with the risk being higher among those who have survived breast cancer. A nationwide analysis in Japan found that breast cancer survivors had a 1.57 times greater risk of developing herpes zoster and a 1.70 times greater risk of postherpetic neuralgia, persistent nerve pain that can occur after a herpes zoster rash.

The highest risk of herpes zoster occurred within the first year after breast cancer diagnosis, and the elevated risk persisted throughout a 10-year follow-up period. Among different treatment modalities, anthracycline-based chemotherapy was linked to a higher risk of herpes zoster. The researchers emphasize the importance of herpes zoster prevention in breast cancer survivorship care, suggesting that vaccination strategies should be considered based on factors like age, treatment history, and immune status.