Mitochondrial stress signaling shapes the nuclear response to loss of the chromatin reader MRG-1
Perinuclear sequestration of heterochromatin is a major conserved feature of nuclear architecture. In Caenorhabditis elegans, the euchromatic reader MRG-1 was previously shown to promote peripheral localization of heterochromatin through an indirect mechanism that remained largely unknown. Here, we show that loss of MRG-1 activates a mitochondrial stress response. Genetic ablation of the…
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