Massive-scale parallel gene synthesis with oligonucleotide hybridization

Nature Biotechnology, Published online: 19 August 2026; doi:10.1038/s41587-026-03290-2 MOSAIC is a high-throughput gene synthesis method driven by hybridization (the self-assembly of complementary oligonucleotides during thermal annealing) instead of enzymatic processing. By using the full capacity of microchip-based oligonucleotide synthesis, MOSAIC enables the parallel production of over 1,000…

nature.com ·11h ago

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