Hypoxia-induced ALDH7A1 expression protects colorectal cancer cells from oxidative stress and DNA damage via a HIF-1-independent mechanism
Tumour hypoxia is associated with increased invasiveness, metastasis, and drug resistance; however, its impact on drug-metabolising enzymes remains poorly understood. This study investigated the effect of hypoxia on the expression of selected aldehyde dehydrogenase (ALDH) isoforms (ALDH1A1, 1A2, 1A3, 1B1, 2, 3A1, and 7A1) in colorectal cancer (CRC) cells. CRC cell lines (HT29, DLD-1, SW480, and…
Colorectal cancer cells exposed to low oxygen levels, a condition known as hypoxia, show increased expression of an enzyme called ALDH7A1. This enzyme plays a crucial role in protecting the cells from oxidative stress and DNA damage. The study reveals that this protective effect of ALDH7A1 is not dependent on a process called HIF-1, which is typically associated with hypoxia response.
The findings suggest that ALDH7A1 may help colorectal cancer cells survive in the hypoxic environment of a tumour. The enzyme's adaptive response to oxidative stress is identified as a potential factor in the survival of colorectal cancer cells within the tumour microenvironment.
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