Structural snapshots reveal key steps in switching on DNA replication

Every time a cell divides, it must accurately copy its entire genetic instruction manual. Before this process can begin, cells load their DNA-copying motor—a complex of six subunits known as the MCM2-7 helicase—onto DNA. However, this motor is deliberately kept inactive to prevent replication from starting at the wrong time.

phys.org ·1h ago

Structural snapshots reveal key steps in switching on DNA replication

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