Improving the diagnosis of primary aldosteronism
A simple new method based on the results of two studies from Christofer Juhlin's research group can make it easier to identify the underlying cause of a common form of high blood pressure and help predict who will benefit most from surgery. The approach has now moved from research into routine patient care at Karolinska University Hospital.
A new diagnostic method developed by Christofer Juhlin's research group simplifies the identification of the cause behind primary aldosteronism, a common cause of high blood pressure. This condition occurs when adrenal glands produce excessive aldosterone, a hormone that regulates salt balance and blood pressure. The innovative approach leverages the B2 ratio, a straightforward measurement comparing the two largest CYP11B2-positive adrenal nodules.
This method can differentiate between nodules that actively produce aldosterone and those with broader aldosterone distribution, aiding accurate diagnosis and predicting surgical outcomes. The B2 ratio has been integrated into routine patient care at Karolinska University Hospital, moving from research to clinical practice.
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