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Genetic dissection of the obesity paradox in carotid atherosclerosis using a hyperlipidemic mouse cohort

Background: Overweight and obese individuals often exhibit lower mortality rates or better prognoses than lean or normal-weight individuals with stroke and other diseases, a phenomenon called the obesity paradox. Carotid atherosclerosis is the primary cause of ischemic stroke, and body weight serves as a reliable surrogate for adiposity in mice. Methods: Phenotypic and genetic connections of…

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